Library

Growth hormone

Peptides from research on the signals around growth hormone, in cell and animal models. Examples are CJC-1295, Ipamorelin and Sermorelin. Strictly for laboratory research, with a certificate of analysis (CoA) per batch on request.

For laboratory and research use only. Not for human or animal consumption, diagnostics or therapeutic use.

The GH-axis research area gathers peptides involved in the axis between the brain and the production of growth hormone. Most compounds here are secretagogues: they prompt the pituitary gland to release growth hormone, or they mimic the signal that normally triggers this release. The research looks at how these signals pulse and how they touch the underlying IGF-1 system.

A feature that sets this area apart is the pulsing rhythm of the release. Growth hormone is not released evenly but in waves, linked in particular to certain phases of sleep. Researchers therefore pay attention to whether a secretagogue follows this natural pattern or flattens it, because the rhythm itself appears to be part of the signal.

GHRH analogues and ghrelin mimetics

Two natural signals drive the release of growth hormone. Sermorelin and CJC-1295 resemble GHRH, the substance that prompts the pituitary. Ipamorelin mimics ghrelin, a separate signal that acts on its own receptor. Researchers study combinations of these two types because they reach the same endpoint through different routes. The pulsing character of the release is an important point of attention here.

IGF-1 as a link further down the chain

Part of the effects of growth hormone runs through IGF-1, a growth factor produced mainly in the liver. IGF-1 LR3 is a modified, longer-acting form of this factor used in laboratory research to study pathways around cell growth. In this way the area shows how a signal at the top of the chain, through the pituitary, eventually carries through to factors further along.

Selectivity of the signal

Not every secretagogue acts equally narrowly. Part of the research concerns selectivity: the question of whether a compound engages only the release of growth hormone or also moves other signals in the pituitary. Ipamorelin is studied in this context because in models it counts as one of the more targeted ghrelin mimetics. This attention to selectivity helps researchers untangle which pathway is precisely responsible for an observed change.

Did you know

GHRH analogues and ghrelin mimetics drive growth hormone release through two separate receptors.
CJC-1295 is designed to remain active longer than the natural GHRH signal.
IGF-1 is produced largely in the liver in response to growth hormone.
Sermorelin corresponds to the first 29 amino acids of the natural GHRH signal.
Ghrelin, the signal that Ipamorelin mimics, is produced mainly in the stomach.

Compounds in this research area

Ipamorelin

Groeihormoonbooster

Ipamorelin is a peptide of five amino acids that fits the ghrelin receptor in the lab. Researchers use it as a reference compound in research on growth-hormone signals.

Target: Spieropbouw · vetverlies · slaap

CJC-1295 (DAC)

Groeihormoonbooster (langwerkend)

CJC-1295 with DAC is a GHRH variant with an extra part (DAC) that makes the compound last longer. Researchers use it as a model compound for long growth-hormone signals.

Target: Spieropbouw · anti-aging

Sermorelin

GHRH(1-29) analog

Sermorelin is a shorter version of GHRH, with the first 29 amino acids. Researchers have long used it as a reference compound for the growth-hormone axis.

Target: GHRH-R

Compare by molecular class

Growth hormone	Type	Target
Ipamorelin	Groeihormoonbooster	Spieropbouw · vetverlies · slaap
CJC-1295 (DAC)	Groeihormoonbooster (langwerkend)	Spieropbouw · anti-aging
Sermorelin	GHRH(1-29) analog	GHRH-R

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Growth hormone