CJC1295 with DAC
€58.99€89.99
-25%
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Research only
CJC-1295 (DAC)
In short
CJC-1295 (DAC) is a Groeihormoonbooster (langwerkend); its molecular target in research is Spieropbouw · anti-aging. Offered strictly for laboratory research, with a certificate of analysis (CoA) per batch on request.
For laboratory and research use only. Not for human or animal consumption, diagnostics or therapeutic use.
TogoPeptide Research Team · Research & quality
Research-only. Fact-checked, no medical or dosing claims. Every batch with a CoA. CoA
CJC-1295 with DAC is a synthetic GHRH analogue used in preclinical research as a model compound for the pituitary growth-hormone axis. Conjugation to a Drug Affinity Complex (DAC) allows the molecule to bind covalently to serum albumin, producing a markedly extended plasma half-life in research models compared with the unconjugated peptide.
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| Type | Groeihormoonbooster (langwerkend) |
|---|---|
| Form | Freeze-dried powder |
| Purity | As stated on the batch CoA |
| Certificate | Per batch, on request |
| Use | Research only |
How does this GHRH analogue differ molecularly from the endogenous hormone?
The molecule is built on the GRF(1-29) fragment, the biologically active portion of native GHRH, with amino acid substitutions at specific positions that increase resistance to degradation by DPP-IV and other proteases. In receptor-binding studies, this modified sequence shows high affinity for the GHRH receptor, a class B G protein-coupled receptor expressed on somatotroph cells of the anterior pituitary. Receptor activation triggers the adenylate cyclase/cAMP/PKA pathway in model systems, the signalling cascade governing growth-hormone synthesis and release.
What does the Drug Affinity Complex do at the molecular level?
DAC consists of a maleimidopropionic acid linker that, once introduced in research models, reacts covalently with a free thiol group on cysteine-34 of circulating serum albumin. This albumin binding shields the peptide from enzymatic degradation and rapid renal clearance. Pharmacokinetic studies in animal models report an elimination half-life spanning several days for the DAC-conjugated form, compared with only minutes for the unconjugated GHRH fragment.
Which research areas use this analogue?
In laboratory settings, the compound is applied in receptor-binding and signal-transduction assays, in studies of growth-hormone axis pulsatility, and in research on downstream IGF-1 signalling. It also serves as a reference compound in comparative research against the non-DAC variant (Mod GRF 1-29), mapping pharmacokinetic differences between short- and long-acting GHRH analogues within controlled model systems.
Why does a Certificate of Analysis matter for this research material?
A CoA confirms batch purity via HPLC and molecular identity via mass spectrometry, alongside screening for microbial load and endotoxins. Documented batch-to-batch consistency is essential for reproducible research outcomes: variation in purity or unintended by-products can skew readouts in receptor or pharmacokinetic assays.
Related products
Every batch with its own CoA
Certificate of analysis per batch and shipping from the EU.
Frequently asked questions
What distinguishes CJC-1295 with DAC from the non-DAC variant?
Both share the same GHRH receptor-binding core sequence, but only the DAC variant carries the albumin-binding linker. This difference produces markedly divergent pharmacokinetic profiles: the DAC variant shows a half-life measured in days in model systems, while the non-DAC variant shows one measured in minutes, making the two complementary reference compounds in comparative growth-hormone axis research.
How exactly does the Drug Affinity Complex bind to albumin?
The linker's maleimide group reacts covalently with the free thiol group on cysteine-34 of serum albumin. This forms a stable conjugate in research models that extends the peptide's circulation time by bypassing the usual degradation and clearance pathways of free peptides.
Why does purity certification matter for research peptides like this analogue?
Only a verified purity profile ensures that observed effects in an assay can be attributed to the intended molecule rather than by-products or contaminants. This is a precondition for reproducible, comparable data across laboratories and studies.
How much does CJC-1295 (DAC) cost?
At TogoPeptide, CJC-1295 (DAC) is available from €58.99 per vial. The price depends on the amount (mg per vial). Every batch comes with a certificate of analysis (CoA), available on request.