Sermorelin Acetate
€47.99€73.99
-25%
Today only on the entire range
02:14:33
Research only
Sermorelin
In short
Sermorelin is a GHRH(1-29) analog; its molecular target in research is GHRH-R. Offered strictly for laboratory research, with a certificate of analysis (CoA) per batch on request.
For laboratory and research use only. Not for human or animal consumption, diagnostics or therapeutic use.
TogoPeptide Research Team · Research & quality
Research-only. Fact-checked, no medical or dosing claims. Every batch with a CoA. CoA
Sermorelin is studied preclinically as a synthetic GHRH analogue comprising the first 29 amino acids of native growth hormone-releasing hormone. As a truncated fragment variant, the molecule serves as a reference peptide for research into GHRH receptor binding, signal transduction in pituitary cell models, and the broader pharmacology of the GHRH-analogue class.
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| Type | GHRH(1-29) analog |
|---|---|
| Form | Freeze-dried powder |
| Purity | As stated on the batch CoA |
| Certificate | Per batch, on request |
| Use | Research only |
What makes Sermorelin a GHRH analogue at the molecular level?
Native GHRH is a 44-amino-acid peptide, but the biologically active domain resides in its N-terminal segment. Sermorelin corresponds to this first 29-residue fragment, GHRH(1-29), which retains the epitope responsible for receptor recognition while presenting a shorter, more synthesis-friendly chain. This truncation is a recurring theme in GHRH-analogue design, where researchers study how sequence length relates to receptor affinity, in vitro stability, and susceptibility to enzymatic degradation.
How does Sermorelin engage the GHRH receptor?
The GHRH receptor (GHRH-R) is a class B G-protein-coupled receptor expressed on somatotroph cells within pituitary tissue used in ex vivo and cell-culture models. In these preclinical systems, GHRH-R activation triggers a signalling cascade from adenylate cyclase to cAMP to protein kinase A, a pathway researchers quantify through cAMP-accumulation assays and receptor-binding studies to characterise ligand-receptor kinetics.
Which research areas examine Sermorelin?
Published preclinical work situates Sermorelin within GH-axis regulation studies, typically using rodent models and isolated pituitary cell systems. Comparative pharmacology within the GHRH-analogue class is another active area, where structural modifications introduced in longer-acting analogues are benchmarked against the Sermorelin fragment as a reference point. In vitro peptide-stability and degradation research also relies on Sermorelin to model how chain length affects enzymatic breakdown.
Why does a Certificate of Analysis matter for Sermorelin research?
Peptide synthesis introduces batch-to-batch variability, so a Certificate of Analysis (CoA) confirming identity through mass spectrometry and purity through HPLC is a baseline requirement for reproducible experimental design. Without verified identity and purity data, GHRH receptor-binding results and comparative analogue studies cannot be reliably interpreted or replicated across laboratories.
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Every batch with its own CoA
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Frequently asked questions
What distinguishes Sermorelin from the full native GHRH molecule?
Sermorelin is the 29-residue N-terminal fragment of the 44-amino-acid native GHRH sequence. Preclinical research indicates this fragment retains the domain responsible for GHRH receptor recognition, making it a practical reference structure for studying receptor pharmacology without the full-length peptide.
How is GHRH receptor activation measured in preclinical models?
Researchers typically use cAMP-accumulation assays and receptor-binding studies in pituitary cell-culture or ex vivo tissue systems, quantifying the adenylate cyclase to cAMP to protein kinase A cascade triggered upon ligand binding.
Why is documentation such as a CoA relevant to research peptides like Sermorelin?
Because peptide synthesis can vary between batches, a CoA verifying identity and purity through analytical methods such as mass spectrometry and HPLC supports reproducibility, a foundational requirement for any comparative or mechanistic study.
How much does Sermorelin cost?
At TogoPeptide, Sermorelin is available from €47.99 per vial. The price depends on the amount (mg per vial). Every batch comes with a certificate of analysis (CoA), available on request.